Angiotensin Modulators/Calcium Channel Blocker Combinations Review

Synthesis and Effects of Novel Dihydropyridines as Dual Calcium Channel Blocker and Angiotensin Antagonist on Isolated Rat Aorta

Objective(s) Four novel losartan analogues 5a-d were synthesized by connecting a dihydropyridine nucleus to imidazole ring. The effects of 5a and 5b on angiotensin receptors (AT') and L-type calcium channels were investigated on isolated rat aorta. Materials and Methods Aortic rings were pre-contracted with 1 pM Angiotensin II or 80 mM KCl and relaxant effects of losartan, nifedipine, 5a and...

Role of valsartan, amlodipine and hydrochlorothiazide fixed combination in blood pressure control: an update

The treatment of moderate or severe hypertension in most cases requires the contemporaneous use of multiple antihypertensive agents. The most available two-drug combinations have an agent that addresses renin secretion and another one that is statistically more effective in renin-independent hypertension. The practice of combining agents that counteract different mechanisms is the most likely e...

Influence of angiotensin II receptor blocker combination tablet prescription on drug number and cost

OBJECTIVES Combination therapy using an angiotensin II receptor blocker is expected to promote medication adherence and alleviate economic burden among patients by reducing the number of drugs taken, and thereby to lower associated medical costs. In the present retrospective study, we conducted a survey on the use of angiotensin II receptor blocker-containing combination tablets as anti-hyperte...

Severe Overdose of Calcium Channel Blocker and Successful Management: A Literature Review and Case Report

Optimizing blood pressure control through the use of fixed combinations

The majority of hypertensive patients need >or=2 antihypertensive agents to reach goal blood pressure. As an estimate, one-third of unselected hypertensive patients may be successfully treated with monotherapy, one-third may require 2 and the remaining one-third of patients will need >or=3 antihypertensive agents for effective blood pressure control. However, doctors are often hesitant to expan...